Health Secretary Matt Hancock will pledge to eliminate HIV transmissions in England by 2030.
Mr Hancock will make the commitment at the Elton John Aids Foundation, Evening Standard and Independent's Aidsfree Cities Global Forum on Wednesday.
He is expected to set a new goal that within the next decade there will be "no new infections", making England "one of the first countries" to reach the UN zero infections target by 2030.
"My generation grew up knowing Aids was a potential death sentence," he will say.
"That doesn't have to be the case any more. Thanks to medical breakthroughs, public health campaigns, breaking down stigma and better education, Aids is no longer a death sentence here.
"I feel proud that Britain has made such progress."
He will add: "So today we're setting a new goal - eradicating HIV transmission in England by 2030.
"No new infections within the next decade - becoming one of the first countries to reach the UN zero infections target by 2030.
"From the ultra local to the truly global. That's the approach we must take to eliminate Aids."
Mr Hancock said he felt angry the progress seen in England was not reflected around the world.
The Department of Health and Social Care said an expert group will develop an action plan for the future.